How can PrescriptFit help with my health conditions and symptoms?

  • What is it?
    Acid Reflux or GERD occurs when acid from the stomach flows backward in the swallowing tube, or esophagus. Typically, this happens because the muscle (sphincter) that keeps the lower end of the esophagus closed once food/liquid passes through to the stomach relaxes more than normal. This reflux often causes stomach pain, heartburn, indigestion, and/or bloating; sometimes, people experience chest pain or difficulty swallowing as a result. Left untreated, GERD can cause serious damage to the esophagus.

    What causes it?
    Physicians really don’t know why reflux occurs more in some people than others. One cause can be mechanical – a hiatal hernia (dislocation of the stomach through the hiatus of the diaphragm and into the chest) allows acid to penetrate the esophagus. Stress causes excess acid secretion, which can make the reflux more likely and more severe. Some medications (such as those often prescribed for arthritis) can dissolve the stomach’s mucous lining, allowing damaging acid to eat away at the stomach. Finally, we know that a bacteria named H. Pylori damages the protective mucous barrier and directly inflames the stomach lining.
    All four mechanisms – mechanical, stress, medications, and bacteria – may be present. In addition, the interrelationship of obesity, diet, and GERD is complex and hard to define.

    What role might cytokines play?
    One theory is that fat cell-produced cytokines influence acid secretion, inflammation, and the ability to move food/liquid through the digestive system. When cytokine-producing diets change to cytokine-balancing diets, these functions improve.

    What results could I expect with MNT?
    In our clinic, 67% of all patients at initial evaluation use some type of antacid medication for symptom relief. Within three months of beginning the PrescriptFit MNT Plan, 87% no longer suffer from GERD symptoms and can discontinue taking antacid medication.

    How can I measure symptom change on the plan?
    First, you need to be clear about what symptoms of GERD you might have. Next, you want to have a measurement of how severe each symptom is for you. This will give you a baseline to compare with future measurements. Most importantly, talk with your doctor at each regular visit about your symptoms and how they might change using the PrescriptFit Plan.

    As with any medical condition, treatment for GERD often involves taking medications to reduce symptoms. With PrescriptFit, you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Angina Pectoris is described as pain, pressure, crushing, pressing, heavy, or breathless discomfort in the chest. Angina may radiate to the back, neck, or down the arms. It may be mild to severe.

    Angina may be precipitated by exertion, emotion, food, smoking, sleeplessness, altitude, and other factors that alter the tone of small blood vessels. It is often worse in the morning.

    Angina can be both disabling and frightening. Usually present prior to a heart attack, angina is often ignored as “indigestion” or associated with fatigue and exhaustion (especially in women).

    What causes it?
    Angina pain originates from the heart, caused by insufficient blood flow through the arteries caused by spasm or cholesterol blockage of coronary arteries.

    What role might cytokines play?
    Small blood vessels react to changes in excess calories, sugar, and fat. Improvement in blood vessel function improves using branched-chain amino acids. Cytokines have direct influence on small vessel lining to cause spasm, increase clotting, and damage collagen that keeps the vessel supple and pliable.

    What results could I expect with MNT?
    Those using the Plan often note immediate and substantial relief of angina, especially in Food Phases 1 and 2. Likewise, patients may experience immediate pain relapse even after a large meal, especially if high in fat and sugar. Angina may be very sensitive to amount of food, type of food, and even preparation of food (as with use of fatty condiments). Remain alert to improvement and relapse of symptoms.

    How can I measure symptom change on the plan?
    Angina can be sporadic or predictable. If your experience with angina is predictable, you will find improvement the easiest to measure. For example, you may feel angina every time you walk to the mailbox or up-hill, then have to rest or take a nitroglycerine tablet to resolve the discomfort. Being able to complete the walk without stopping would be a measurable improvement you could readily see. If your experience with angina is more sporadic, it may take some time to see a trend that indicates fewer episodes of discomfort.

    First, you need to make sure that you see your physician immediately for any symptoms of angina that have not been previously diagnosed. Your doctor will prescribe treatment after determining what course of cardiac care is best for you. MNT can support your treatment with the combined benefits of branched-chain amino acids and how you monitor changes throughout the Food Phases.

    Next, you want to have a measurement of how frequent, severe, and long lasting each episode of angina is for you. This will give you a baseline to compare with future measurements.

  • What is it?
    Asthma can be caused by an allergic reaction or triggered by a number of factors not related to allergies. Exercises, exposure to cold air, or heartburn are some non-allergy related triggers. Environmental factors such as tobacco smoke, pollutants, and stress, as well as biological factors, related on ones internal chemistry, appear to trigger attacks.

    What causes it?
    The main contributor to asthma is inflammation within the lungs. This leads to constriction of the airway muscles, stimulation of mucous production, and flooding of the airways with inflammatory cells.

    What role might cytokines play?
    Cytokines trigger inflammation that may result in asthma. Branched chain amino acids may improve out of balance cytokines and significantly reduce symptoms. Most new asthma medications directly attack cytokines (called leukotrienes). Therefore, logic dictates a trial of MNT to measure asthma improvement.

    What results could I expect with MNT?
    Based on clinical data, asthma improves in many patients using the MNT Plan, especially in Food Phases 1 and 2. Additionally, PrescriptFit may improve asthma by removing the thousands of different nutrients, bacteria, and chemicals in a normal diet. Food Phases 1 and 2 of the Plan limit exposure to nutrients and particles that might trigger inflammation. As a specific food group is added in, note if asthma worsens. A specific food group may contribute to asthma in one person but not another. Those foods high in fat, sugar, and dairy products should be especially monitored to see if symptoms worsen after eating.

    How can I measure symptom change on the plan?
    First, see your doctor right away for any symptoms of asthma. Have you doctor share with you what measurements indicate that you have asthma and if your asthma might be from an allergy. Next, complete the Disease/ Symptoms Questionnaire in your Workbook Calendar for a baseline to compare your future measures.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with you doctor at each regular visit about your symptoms and how they might change using the Plan. Be sure to have your doctor take the same measurements after 12 weeks on the MNT Plan as you had taken at the baseline mark.

    With PrescriptFit, you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take.

  • What is it?
    Diabetes mellitus results from your pancreas being unable to produce enough insulin to act on the sugar content in your bloodstream. Diabetes is defined as a fasting (12-hour fast) blood glucose (known as FPG) of 126 mg/dl or greater or a glucose level of 200 mg/dl or greater after a meal. A pre-diabetes condition exists when the fasting blood sugar is 110 mg/dl or above.

    What causes it?
    Diabetes occurs when the pancreas does not produce sufficient insulin, which is a hormone essential for protein, fats, and sugars (glucose) to enter cells for growth and repair or energy production. When cells become resistant to the action of insulin (due to diet, lack of exercise and genetic factors), cells think they are starving and send messages to the pancreas to produce more insulin (which is still ineffective). As a result, the pancreas becomes exhausted from chronic overproduction of insulin.
    Visualize a muscle pumping a weight. When the muscle becomes exhausted, the weight cannot be pumped or picked up no matter how hard the person tries. If the muscle is rested and re-energized, the weight can again be pumped. The pancreas is similar. Years or decades of chronic insulin overproduction will cause exhaustion. Resting the pancreas with diet and improving muscle cell sensitivity restores the pancreas to proper function without medication.

    What role might cytokines play?
    Cytokines have been discovered that promote cell resistance to insulin (called resistin). Diet and exercise are shown to balance these cytokines, helping the body fix the metabolism errors common in diabetes and restore pancreas insulin production.

    What results could I expect with MNT?
    MNT is the primary treatment for type 2 diabetes mellitus. Medication should be added only after diet fails to produce significant changes in blood sugar. Many people with diabetes experience something called diabetic neuropathy, which is nerve damage, frequently described as burning in the feet or legs. These symptoms typically improve, especially if present for only a few years. Other conditions related to diabetes usually improve with MNT as well, including: hypertension, edema (swelling), elevated cholesterol/triglycerides, sleep disorders, fatigue, and depression. Study each applicable disease section, and complete the Disease/Symptom Questionnaires in the Workbook Calendar to track exactly how MNT helps with diabetes-related symptoms.

    How can I measure symptom change on the plan?
    You need to be clear whether or not you have Type 2 adult onset diabetes mellitus. If monitoring blood sugar with a home test kit (available at pharmacies), record daily glucose readings until they are normal and stay normal (FPG level at less that 126 mg/dl). If you take medications for diabetes, your physician should closely supervise your treatment throughout the MNT Plan.

  • What is it?
    Steatosis, or fatty liver, is the most common form of chronic liver disease, replacing alcohol and viral hepatitis as the most common cause of cirrhosis of the liver. Patients with fatty liver and alcoholism or viral hepatitis are much more likely to have liver cell damage and cirrhosis.

    What causes it?
    Fatty liver is caused by the accumulation of triglyceride fat deposits within liver cells due to abnormal liver metabolism. Excessive fat in liver cells provokes inflammation and activates the immune system. Simple blood tests can suggest the presence of inflammation caused by these deposits but cannot assure the definitive cause.
    Because the only way to prove a diagnosis of steatosis is to perform a biopsy of the liver (which carries a risk of bleeding), many physicians make the diagnosis by exclusion. That is, for those who have neither a history of alcoholism nor lab results indicating a viral/ immune liver disease, there is a 90% chance that your symptoms indicate a fatty liver – odds reasonable enough to avoid biopsy.

    What role might cytokines play?
    Most patients with fatty liver are overweight. Patients with fatty liver have elevated levels of inflammation cytokines (CRP, IL-6, TNF). Patients with fatty liver often have diabetes or pre-diabetes (IRS), conditions also associated with abnormal cytokine production. Studies suggest the fat accumulation and the inflammation of the liver cell are related but independent abnormalities. Common cytokines may play a role in both, and nutrition may be the common mediator.

    People with fatty liver tend to be more likely to suffer with metabolic syndrome (insulin resistant syndrome) and eventually become diabetic. They have a higher rate of hypertension and sleep apnea as well as elevated cholesterol and triglyceride levels.

    What results could I expect with MNT?
    MNT is the first line of treatment for fatty liver, especially because of the Plan’s ability to help reduce your triglyceride levels. Patients using the Plan to improve laboratory tests of fatty liver usually by the end of Food Phase 8 of the 7 day Plan or Food Phase 4 of the 14 day Plan. Your physician should perform liver function tests (SGOT, SGPT, and alkaline phosphatase blood tests) every 12 weeks when using the Plan.

    How can I measure symptom change on the plan?
    Improvement in fatty liver enzyme results must be measured by your physician. Measurement should be considered every 12 weeks until your lab results indicate that the maximum response has been achieved.

  • What is it?
    Fibromyalgia is a complex chronic condition of unknown origin that affects women far more than men (80% to 90%) and those typically over 20 years of age. The condition involves pain in the muscles and soft tissue for which no diagnostic test can determine cause (e.g., blood tests, x-rays, MRI, CAT scan, etc.) Muscle and bone surfaces are typically most tender. Although fibromyalgia does not appear to shorten one’s lifespan nor necessarily be physically debilitation, it is highly recurrent – full recovery is rare. However, with good support and treatment (usually involving some medication, good sleep habits, and exercise), fibromyalgia will not severely damage quality of life.

    What causes it?
    We really know very little about fibromyalgia; however, many theories exist regarding its cause. Some believe that the disorder is linked to viral infection, psychological disturbances or trauma, altered pain perception, lack of growth hormone, or lack of exercise. Other researchers point to change in sleep patterns or low levels of serotonin – a hormone that regulates moods and sleep.

    Female hormones are known to affect many brain and nerve neurotransmitters, including pain-mediating ones.

    What role might cytokines play?
    Scientists point to Substance P (also known as neurokephlin) as a chemical in our bodies that modifies pain sensation in nerve fibers and brain cells. Research indicates that Substance P abnormalities may effect depression and are abnormal in fibromyalgia. Because cytokines produced by fat cells influence production and function of Substance P and female hormones regulate fat cell physiology, this link between obesity, cytokines, hormones, and pain regulation is very plausible.

    What results could I expect with MNT?
    Cases of fibromyalgia often improve following the PrescriptFit MNT Plan, although response is difficult to predict. Most cases improve by Phase 1 or 2, especially when using the 7- or 14-day Food Phase Plan. You should see a change in symptoms by the end of week 4 if you rigidly adhere to the Plan.

    Most patients experience improved sleep (and less fatigue) the quickest, followed by improved mood. Pain usually improves after sleep improves.

    How can I measure symptom change on the plan?
    Learn what may be causing your muscle pain and other symptoms. Visit your physician to determine whether you have fibromyalgia. Talk with your doctor about MNT and its impact on sleep, fatigue, depression, and other symptoms you’re experiencing. Next, you want to have measurement of how severe each symptom is for you. This will give you a baseline to compare with future measurements.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the Plan.

    As with any medical condition, treatment traditionally means taking medications to reduce symptoms. You may find that as your symptoms lessen with MNT, you will need to take less medication OR perhaps discontinue pain medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Hyperlipidemia is literally the presence of too much fat in the bloodstream. With this condition, you will have elevated cholesterol counts (LDL, HDL, and total cholesterol) and/or triglycerides. Excess levels of these fats speed up the process of hardening of the arteries, which reduces blood flow and can cause heart attack or stroke.
    Lowering cholesterol and triglyceride levels decreases this risk. Although some experts believe that current guidelines are not conservative enough, physicians recommend that, to minimize your risk of heart disease, your desirable lipid levels should be:

    • LDL less that 130 mg / dL(ideal less that 70)

    • HDL greater than 40 mg / dL(men) or 50 mg / dL(women)

    • Total cholesterol less than 200 mg / dL(ideal less than 150)

    • Triglycerides less than 150 mg / dL


    Medications are often required to achieve these levels; however, therapeutic lifestyle changes (TLC), including healthy diet and exercise choices, are considered the first line of treatment.

    Elevated cholesterol levels do not absolutely predict blockage. Imaging technology may help measure degree of artery blockage. Carotid artery ultrasound and coronary artery calcium deposits can be measured. Coronary calcium scoring is more expensive, and it requires a CT scan.

    What causes it?
    There are two types of hyperlipidemia:

    • The type that runs in families. If a close relative had early heart disease (father or brother affected before age 55, mother or sister affected before age 65), you also have an increased risk.

    • The type caused by lifestyle habits or treatable medical conditions. Lifestyle-related causes include obesity, being sedentary, and smoking. Medical conditions that cause hyperlipidemia include diabetes, kidney disease, pregnancy, and having an underactive thyroid gland.


    What role might cytokines play?
    The study of atherosclerosis (hardening of the arteries) is now focused primarily in inflammation of the arteries rather than nutritional overload of the bloodstream with fat (although both are important). Cytokines are the primary mediator of inflammation and the focus of most research now is how to reduce cytokine-induced inflammation damage to the arteries. Inflammation leads to cholesterol deposits within the artery, collagen damage resulting in hardening or calcification of the artery, and clotting on the damaged surface of the inflamed artery. Diet plays a role in promoting or reducing the degree of inflammation cytokines produce. The PrescriptFit MNT Plan optimizes protection from excess cytokine production.

    What results could I expect with MNT?
    For most of our patients, Food Phases 1 and 2 are associated with the most profound decreases in cholesterol and triglyceride levels. You may see rises in cholesterol levels with some Food Phases that involve some saturated fats, such as those that allow poultry, eggs, pork, beef, dairy, or baked goods. Nuts may actually lower cholesterol levels.

    Proving you can control cholesterol with diet, then demonstrating which foods elevate cholesterol, makes infinitely more sense than initially taking a cholesterol-lowering medication. Even if medication is required, diet management is still very important. The learning curve provided by the MNT Plan can be invaluable in deciding if a particular food should be avoided or medication required.

    How can I measure symptom change on the plan?
    First, talk to your doctor about your cholesterol and triglyceride levels as well as your risk level, in general, for heart disease. Have your doctor share with you what your last lipids screening results were. This will give you a baseline to compare with future measurements. Next, purchase a cholesterol testing kit at a local pharmacy (available without a prescription). Test your cholesterol level every four weeks if using the recommended 7 or 14 day Plans.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the PrescriptFit Plan. Share your test results with your doctor.

    As with any medical condition, treatment may mean that you are taking medications to reduce your cholesterol. With MNT, you may find that as your symptoms lessen, you need less medication.

  • What is it?
    Infertility is a complex disorder that occurs in both men and women. It is a disease of the reproductive system that prevents conception and can occur because of problems with any facet of the reproductive process.

    What causes it?
    For women, most infertility cases stem from some problem with ovulation. Each step of the process from egg maturation to implantation may be influenced by dietary factors. There is an apparent relationship between infertility and obesity, especially in those who have insulin resistance syndrome (IRS).

    What role might cytokines play?
    In the early 1990s, researchers discovered a hormone produced by fat cells – leptin – that helps regulate food intake and metabolism as well as fat storage in the cells. Subsequently, leptin was found to play a role in fertility. As excess nutrition and obesity develop, especially in insulin-resistant individuals, “resistance” to the action of leptin also develops.

    What results could I expect with MNT?
    Although the link between MNT and fertility is not clear-cut, there appears to be one: Women with IRS (insulin resistant syndrome) are especially likely to benefit from MNT, partially because polycystic ovary syndrome is characterized, possibly even caused, by insulin resistance. Additionally, obesity influences leptin, a hormone important in regulation the entire process of conception.

    A group of obese women treated in our clinic for infertility with MNT have conceived within three months, indicating that “the diet” rather than the obesity contributed to the infertility. Women who are amennorrheic (without periods) typically resume menstrual periods within the first eight weeks with rigid adherence to Food Phases 1 and 2 of the Plan.

    How can I measure symptom change on the plan?
    First of all, infertile couples should undergo evaluation by a fertility specialist prior to considering the PrescriptFit MNT Plan to determine possible causes and treatment solutions. Talk to the specialist about trying MNT prior to medication or other therapies.
    Fertilization can best occur two weeks following a menstrual period when the woman ovulates. To better pinpoint when ovulation occurs, women can use:

    • Calendar tracking – Record past menstrual cycle start date and duration to determine when you are most likely to be fertile.

    • Taking basal body temperature – Use a basal thermometer to check your body temperature each morning before becoming active. A rise of 0.4 to 1 degree Fahrenheit occurs when you ovulate.

    • Checking vaginal mucus – Daily test vaginal mucus for color (yellow, white, clear or cloudy), consistency (thick, sticky, or stretchy), and feel (dry, wet, sticky, slippery, stretchy). Ovulation probably occurs the same day that your mucus is clearest, most slippery, and most stretchy.

  • What is it?
    IBS is one of the most common maladies affecting adults. As the name implies, IBS feels like the bowel is irritable or “angry.” People with IBS experience cramps, diarrhea, feelings of constipation, and generalized abdominal pain usually experienced in the lower abdomen. “Bloating” is a common complaint, especially after meals.

    What causes it?
    There may be several causes for IBS. One of the more common is the inability to digest certain sugars. Without digestion, these sugars ferment into the gases methane, butane, and formate. These gases are irritating to the gut, produce abnormal motility, and are quite smelly (they are components of “swamp gas” and are quite flammable). These gases have also been associated with generalize muscle pain (similar to fibromyalgia).

    You should see your doctor about any ongoing abdominal pain. You will probably need to have some diagnostic tests performed to rule out serious gut disease – peptic ulcers, cancer, ulcerative colitis, or Crohn’s Disease (ileitis).

    What role might cytokines play?
    Cytokines probably play a minimal role in IBS, although the relationship to diet and gut hormone production is being studied. We know that specific gut hormones [e.g., cholecystokinin (CCK), ghrelin, motilin, gastrin] are released in different amounts and patterns depending on meal consistency. We also know that inflammatory cytokines are related to an abnormal amount or pattern of gut hormone release. However, no consistent cause-effect relationship has yet been established.

    What results could I expect with MNT?
    This Plan is an ideal way to test for and improve symptoms of IBS. Many patients improve or resolve using PrescriptFit strategies without the need for costly tests or medication. In our clinical experience, most patients report rapid results, often noting improvements the first week.

    Food Phase 1 requires use of PrescriptFit lactose-free products only (no other food). You should take at least eight doses per day along with a complete multivitamin. You may consume as many as 20 doses per day, if needed, to feel satisfied.
    If you are taking medication, especially for high blood pressure, diabetes, acid reflux, or cardiac disease, your physician will need to carefully monitor your condition throughout the Plan.

    Food Phases likely to cause symptom recurrence are vegetables, fruit, dairy products, and starchy foods. Sugars found in milk, fruit, beans (legumes), and wheat ferment in the gut to form methane, butane, and formate. By adding each food group sequentially, you can identify and then avoid the offending foods. Use this four-step, trial-and error approach to “weed out” the foods that make you feel bad:

    • If symptoms increase during a particular Food Phase, simply skip that phase.

    • Continue adding Phases and note symptoms.

    • If symptoms occur in subsequent Food Phases, skip those phases as well until all 13 Food Phases are complete.

    • Sequentially add previously offensive Food Phases and note results.


    What results could I expect with MNT?
    First, you need to be clear about what symptoms of IBS you might have. Next, you want to measure how severe each symptom is for you. This will give you a baseline to compare with future measurements. Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the PrescriptFit Plan.

  • What is it?
    Insulin is a hormone manufactured in the pancreas and released into the bloodstream when you consume carbohydrates, fats, and protein. Insulin regulates how your body metabolizes carbohydrate, fat, and protein by allowing these nutrients into your cells. The amount of insulin released is finely controlled by a feedback messaging system that relays how quickly and effectively nutrients enter individual cells (especially in the liver and muscle).

    If the receptor at the cell surface no longer allows insulin to “land” on the cell, excess insulin accumulates in the bloodstream. Despite this overabundance of insulin in the bloodstream, the pancreas “thinks” that your body needs more insulin because the relay system isn’t working properly and produces and secretes even more. This resistance to the action of insulin is known as the insulin resistant syndrome (or IRS).

    Other terms related to IRS include prediabetes and metabolic syndrome; however, these terms mean slightly different things.

    Prediabetes is defined as a time period (perhaps lasting year or decades) prior to a diagnosis of diabetes when insulin metabolism in unhealthy. After years or decades of overwork, the pancreas becomes “exhausted” from the excess insulin production and fails. The result is type 2 diabetes mellitus (thus giving rise to the term, “prediabetes”).

    Metabolic syndrome is defined as a group of conditions (i.e., type 2 diabetes, obesity, high blood pressure, and cholesterol problems) that place people at high risk for coronary artery disease. All of the conditions in this group are related to one having excess insulin in his/her bloodstream, which causes defects, especially to adipose tissue and muscle.

    Long before obvious diabetes develops, elevated insulin levels in the bloodstream can lead to abnormal metabolism, causing a number of different medical conditions – hypertension (high blood pressure), hyperlipidemia (elevated cholesterol and triglycerides), fatty liver (steatosis), sleep disorders, infertility, and depression. Although IRS can be defined as a cluster of abnormalities (e.g., obesity, hypertension, etc.) associated with insulin resistance and over-secretion of insulin by the pancreas, a cause-and-effect relationship between insulin resistance and the development of these diseases has yet to be conclusively demonstrated.

    What determines if you have metabolic syndrome?
    Physicians determine if patients might have IRS by looking for any three of the following:

    Large waist size:
    Does your waist measure more than 35 inches (females) or more than 40” (males)?
    Blood pressure:
    Is your blood pressure greater than 130 systolic/85 diastolic?
    Fasting blood sugar (FPG):
    Do the results of the blood sugar test your doctor runs indicate a blood sugar rate higher than 110?
    Fasting triglycerides:
    Do the results of a lipid screening indicate that blood levels of triglycerides are greater than 150?
    HDL cholesterol:
    Is your HDL cholesterol at an unhealthy level – less than 40 (for men) or 50 (for women)?

    What role might cytokines play?
    A cytokine manufactured by fat tissue, called adiponectin, is the primary factor preventing insulin resistance. Decreasing adiponectin level are associated with increasing insulin levels and diminished insulin function. Diets high in calories, saturated or trans fats, and simple carbohydrates lower adiponectin levels, causing insulin resistance.

    Another cytokine manufactured by fat tissue, resistin, causes lower adiponectin levels. Resistin also inhibits the function of insulin on cell surfaces. Elevated resistin secretion is seen in diets high in calories, saturated or trans fat, and simple carbohydrates.
    Many fat and liver produced cytokines affect adiponectin and resistin levels.

    Understanding the intricacies of cytokine balance with nutrition is in the earliest phases.
    Because having excess adipose (fat) tissue negatively affects how your body regulates insulin production and metabolism, losing weight on a safe, easy-to-follow plan like MNT can’t help but ensure success reducing IRS symptoms. Additionally, the overproduction of cytokines due to excess adipose tissue will likely be reduced by the action of the branched-chain amino acids in PrescriptFit shakes and soups.

    What results could I expect with MNT?
    Based on our clinical experience, insulin resistance gets better within days to weeks in patients using the PrescriptFit MNT Plan. Although the mechanism for how this occurs is unclear, the result is improved sugar metabolism, lower cholesterol, and lower blood sugar.

    How can I measure symptom change on the plan?
    Note that some measurements associated with monitoring IRS must be done by your doctor or in a health care setting, especially tests for cholesterol and blood sugar levels in your bloodstream. Of course, you can monitor your waist size, weight, and blood pressure at home.

    First, have your doctor share with you what measurements indicate that you have IRS from the Disease/ Symptom Questionnaire in the Workbook Calendar. This will give you a baseline to compare with future measurements.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change following the PrescriptFit Plan. Be sure to have your doctor take the same measurements after 12 weeks on the MNT Plan as you took at the beginning.

    As with any medical condition, treatment may mean that you are taking medications to reduce symptoms associated with IRS (e.g., hypertension). With PrescriptFit you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Sleep apnea is a sleep disorder that affects some 18 million Americans and can be very serious if not treated. People with this disorder stop breathing for 10 to 30 seconds at a time while they are sleeping, possibly as many as 400 times each night. These periods of not breathing often wake people from deep sleep, seriously reducing the amount of necessary rest they are actually getting.

    Those with sleep apnea typically suffer progressive fatigue, tiredness, malaise, depression, and muscle stiffness. Sleep apnea is associated with increased of risk heart attack and stroke. In addition, this common disorder can lead to disability and death (e.g. falling asleep at the wheel while driving).

    Treatment typically involves use of dental devices, equipment that increases air pressure to increase restful breathing during sleep, and weight loss.

    What causes it?
    Obstructive sleep apnea is what 9 out of 10 people with sleep apnea have and is caused by something blocking the passage or windpipe (called the trachea) that brings air into your body. That something may be:

    • The tongue, tonsils, or the uvula (the small piece of flesh hanging down in the back of the throat).

    • Excessive fatty tissue in the throat; many of those with sleep apnea are obese.

    • Abnormally relaxed throat muscles, due to poor function of the nerves from the lower brain that control breathing and swallowing. Evidence suggests that the poor nerve function is related to abnormal metabolism.


    What role might cytokines play?
    The exact role that cytokines have on sleep in unknown. Studies show that most sleep apnea patients have excess levels of cytokines associated with inflammation, which attach directly to nerve cells in the brain, including the areas that control breathing and swallowing.

    What results could I expect with MNT?
    MNT is the first line of treatment recommended in obese or overweight patients with sleep disorders. Patients using the Plan note improvement in fatigue by the end of Food Phases 1 and 2 of the 7 to 14 day Plans.

    With MNT many patients can eventually discontinue annoying and expensive sleep devices. To many people’s surprise, nutritional diets appear to be far more important that weight loss in treating sleep apnea. In most patients, improvement in fatigue and snoring diminishes long before large weight loss is noted. In fact, patients who undergo gastric bypass operations often can stop using special breathing devices for sleep apnea within weeks – long before they experience significant weight loss.

    How can I measure symptom change on the plan?
    First, you need to be clear about what may be causing your sleep apnea. Although rare, there is a second type of sleep apnea (central sleep apnea) that occurs when the muscles you use to breathe fail for some reason to receive the signal to do so from your brain. You should work with your physician to clearly identify which type of sleep apnea you have and what would be the best treatment approach. Talk with your doctor about the effects that MNT may have on your treatment. Next, you want to measure how severe each of the two key sleep apnea symptoms are for you. This will give you a baseline to compare with future measurements.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the Plan.

  • What is it?
    Fatigue, characterized as physical and/or mental weariness, occur either as a symptom of illness or as a side effect of medication. Normal fatigue occurs as a result of exertion, stress, or dealing with illness (e.g., fighting off a cold).

    What causes it?
    Common, reversible causes of fatigue are sleep disorder, depression, cardiac disease, anemia, and hypothyroidism. High blood pressure, depression, antihistamine, sleeping, and anti-anxiety medications may also cause fatigue related side effects.

    What role might cytokines play?
    Cytokines most likely impact fatigue via disturbances in brain function with resultant sleep disturbances, such as sleep apnea. Additional fatigue occurs when there is a malfunction in the cardiopulmonary system that results in restless sleep due to poor breathing. Finally, fatigue may be due to stress hormones (adrenalin and cortisone) induced by excess cytokine production in fat and liver cells. Improvement in symptoms is clearly related to improvement in toxic cytokine levels (TNF, IL-1 and IL-6, CRP, and others).

    What results could I expect with MNT?
    Fatigue often responds to the MNT Plan, regardless of cause. It is also one of the symptoms to return quickly with overeating/ weight gain.

    Fatigue is an important symptom to follow with each progressive Phase, typically responding to the first two Food Phases of the Plan.

    How can I measure symptom change on the plan?
    First, you need to be clear about what may be causing your fatigue. Your physician may need to evaluate you for cardiac illness, hypothyroidism, anemia, or major depressive disorder.
    Because many medications associated with fatigue side effects are prescribed for other conditions that respond to MNT, you and your doctor may find over time that your need for these medications will diminish. Take a baseline measurement of your fatigue and re-measure after each Food Phase or every four weeks.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they have changed using the Plan. As with any medical condition, treatment traditionally means taking medications to reduce symptoms. With MNT, you may find that you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Dyspnea, or breathlessness, is any perceived difficulty breathing or pain you feel when breathing. It can be a symptom of many disorders, especially:

    • Cardiac disease (coronary obstruction, CHF, valve disease, other)

    • Pulmonary disease (asthma, emphysema, other)

    • Kidney and/or Liver disease with edema (swelling)

    • Anemia (iron deficiency, B-12 deficiency, other)

    • Hypothyroidism


    What causes it?
    Breathlessness may be caused by medical conditions or simply by excessive weight. Breathlessness may be a symptom of underlying cardiac disease. Physician evaluation is recommended, including a cardiac stress test and cardiac ultrasound exam. A chest x-ray is also indicated, especially in smokers.

    If breathlessness resolves during Food Phase 1 or 2, cardiac causes are still possible. One would not expect breathlessness from excess weight to improve within 4 weeks of treatment, as only a minimal amount of weight would be lost relative to total needed to lose.

    What role might cytokines play?
    Cytokines are intimately involved with the function of small blood vessels and inflammation. While dyspnea is a symptom, it is related to cardiopulmonary function. Relaxing of the pulmonary (lung) small blood vessels and the small blood vessels downstream from the heart improve circulation, improve oxygen exchange, and therefore improve dyspnea or breathlessness.

    What results could I expect with MNT?
    In our experience, dyspnea improves very rapidly, in most cases, regardless of the primary cause (with the exception of emphysema). Most symptoms are measurably better in the first week. It’s very reinforcing to track your ability to breathe better after each Plan phase. At the very least, improvement should be noted within four weeks. Breathlessness beyond this point is usually not improved by MNT.

    Occasionally, a specific food may precipitate fluid retention, blood vessel spasm, or bronchial spasm leading to relapse of breathlessness. If breathlessness recurs when adding any specific food group, restart Food Phase 1 (with physician notification and supervision) and continue until symptoms resolve. Add the subsequent Food Phases slowly (every one to two weeks) and cautiously.

    How can I measure symptom change on the plan?
    First, visit your physician to determine the cause of your breathlessness. Next, take a baseline measurement of the degree of discomfort you feel. Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the Plan.

    As with any medical condition, treatment may mean that you are taking medications to reduce your dyspnea symptoms. With this Plan you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Acid Reflux or GERD occurs when acid from the stomach flows backward in the swallowing tube, or esophagus. Typically, this happens because the muscle (sphincter) that keeps the lower end of the esophagus closed once food/liquid passes through to the stomach relaxes more than normal. This reflux often causes stomach pain, heartburn, indigestion, and/or bloating; sometimes, people experience chest pain or difficulty swallowing as a result. Left untreated, GERD can cause serious damage to the esophagus.

    What causes it?
    Physicians really don’t know why reflux occurs more in some people than others. One cause can be mechanical – a hiatal hernia (dislocation of the stomach through the hiatus of the diaphragm and into the chest) allows acid to penetrate the esophagus. Stress causes excess acid secretion, which can make the reflux more likely and more severe. Some medications (such as those often prescribed for arthritis) can dissolve the stomach’s mucous lining, allowing damaging acid to eat away at the stomach. Finally, we know that a bacteria named H. Pylori damages the protective mucous barrier and directly inflames the stomach lining.

    All four mechanisms – mechanical, stress, medications, and bacteria – may be present. In addition, the interrelationship of obesity, diet, and GERD is complex and hard to define.

    What role might cytokines play?
    One theory is that fat cell-produced cytokines influence acid secretion, inflammation, and the ability to move food/liquid through the digestive system. When cytokine-producing diets change to cytokine-balancing diets, these functions improve.

    What results could I expect with MNT?
    In our clinic, 67% of all patients at initial evaluation use some type of antacid medication for symptom relief. Within three months of beginning the PrescriptFit MNT Plan, 87% no longer suffer from GERD symptoms and can discontinue taking antacid medication.

    How can I measure symptom change on the plan?
    First, you need to be clear about what symptoms of GERD you might have. Next, you want to have a measurement of how severe each symptom is for you. This will give you a baseline to compare with future measurements. Most importantly, talk with your doctor at each regular visit about your symptoms and how they might change using the PrescriptFit Plan.

    As with any medical condition, treatment for GERD often involves taking medications to reduce symptoms. With PrescriptFit, you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Headache is a common symptom that may result from a number of different problems or illnesses. Headaches are classified as either primary or secondary. Primary headaches are those that occur without appearing to be caused by another illness, such as tension headaches or migraines. Secondary headaches can result from a number of conditions. These may range from life threatening brain tumors, strokes, and meningitis to less serious problems, such as caffeine or pain medication withdrawals.

    What causes it?
    There are 3 types of headaches:

    [MIGRAINE] A throbbing headache that usually originates in the front or side of the head. Its cause is really not known; however, a number of triggers have been identified, such as stress, sleep disturbances, hormones, bridge or flickering lights, certain odors, cigarette smoke, alcohol, aged cheese, chocolate, monosodium glutamate, nitrites, aspartame, and caffeine.

    [PSEUDOTUMOR CEREBRI] is a condition due to excess spinal fluid pressure; it is most common in people who gain weight and become obese, especially women. The cause is unknown.

    [MUSCLE TENSION HEADACHES] often appear to be related to posture problems that occur in those with large abdomens or breasts and improve with treatment for the neck muscles involved. Muscle tension or traction headaches from excess weight may take longer to resolve and be related to total weight loss.

    What role might cytokines play?
    Migraine is due to swelling and inflammation of brain blood vessels. This swelling and inflammation cause irritation of brain nerve fibers which then convey pain across the head and face. The swelling and inflammation are mediated by proteins in the cytokine class. As in other illness, genetic factors play a role. It is possible the inflammatory and swelling related cytokines generated from fat cells, liver, and intestine contribute to these genetic migraine trigger in obesity.

    Why pseudotumor respond to MNT is also unknown. Hormones and cytokine proteins control spinal fluid regulation in the brain. Cytokines from fat tissue may influence formation or removal of spinal fluid. Only a spinal puncture can diagnose psuedotumor. If headache responds to the PrescriptFit MNT Plan, pseudotumor should be considered likely, even without a spinal puncture.
    Since pseudotumor predominately affects women, hormones obviously play a role. Exactly how fat-produced cytokines and hormones interplay to prevent removal of spinal fluid is unknown. However, it is likely that cytokines mediate the process. Why? Because headache improves and pressure measures from spinal puncture register decreases in days or week after starting the PrescriptFit Plan, long before substantial weight loss occurs.

    Muscle tension headaches will only improve at the rate that the mechanical strain that causes it improves. Weight loss and decreased inflammation will help alleviate mechanical strain sooner. Headaches that improve rapidly on the Plan are probably due to another cause.

    What results could I expect with MNT?
    Clinical experience with MNT and headache varies with the cause. Pseudotumor responds within days or weeks but requires a spinal puncture for confirmation. Migraine may respond quickly; however, it has many triggers and a naturally variable course. Therefore, long-term response can be gauged only by recording headache scores on the Disease/Symptom Questionnaire (Workbook Calendar) over time (e.g., monthly for at least a year). Muscle tension headaches should respond based on total weight loss.

  • hat is it?
    People who suffer from insomnia get either too little sleep or the sleep they get is not very restful and refreshing. The problem does not necessarily have anything to do with the number of hours you sleep at night; it has to do with the quality of that sleep. For some, the problem is having trouble falling asleep in the first place. For others, the chronic tiredness comes from waking up too early in the morning. Some people fall asleep with no trouble, but wake up several times during the night and struggle to get back to sleep.

    No matter what the pattern, insomnia leaves you feeling tired, sometimes even after sleeping 7 to 8 hours. This lack of adequate rest causes problems during the day – excessive sleepiness, fatigue, trouble thinking clearly or staying focused, or feeling depressed/irritable.

    What causes it?
    Insomnia may be a temporary problem induced by situational stress at home or at work, having a poor sleep environment (too much light, noise, or a partner who snores), or even certain medications. This type of short-term or occasional insomnia can last from a single night to a few weeks or occur from time to time.

    If insomnia persists for at least three nights a week for over a month or more, you should see your physician about possible underlying medical causes. If this is not the case, your physician can help you identify patterns (working erratic shifts, not exercising, drinking caffeine or alcohol too close to bedtime, etc.) that might help positively alter your sleep patterns.

    What role might cytokines play?
    How MNT improves insomnia is unknown. A majority of patients presenting to our clinic complain of insomnia. A majority improve sleep when following the Plan. Some improvement may be due to other related medical conditions, such as sleep apnea, acid reflux, or even improved oxygen exchange from better blood flow. No specific cytokines have been related to general insomnia related to anxiety. Perhaps, improved metabolism related to balanced cytokine production (see other disease sections) lowers adrenalin and cortisone levels, which are known to aggravate insomnia.

    What results could I expect with MNT?
    Those suffering from insomnia often note improvement on the MNT Plan. Why this occurs is unknown; however, we suspect that improved brain function is related to improved nutrition or improved metabolism. Also, we know that branched-chain amino acids benefit patients suffering from a number of conditions that cause insomnia (depression, acid reflux, sleep apnea, arthritis, etc.), and not getting enough restful sleep complicates these conditions. Because of this interplay, you don’t know if your insomnia got better because your arthritis symptoms eased (for example), or whether your arthritis symptoms improved because you’re finally getting a good night’s rest on a regular basis.

    How can I measure symptom change on the plan?
    First, you need to be clear about what might be causing your insomnia. Talk to your doctor about your medical and sleep history. Find out if there is an underlying medical problem that needs attention.

    If you have chronic insomnia, you will want to measure how severe each symptom is for you. This will give you a baseline to compare with future measurements. Most importantly, you (and your doctor) need a way to measure progress over time. Measure your symptoms again after four weeks of following each Food Phase. Take the results to your doctor and discuss how your symptoms have changed using the Plan.

  • What is it?
    Edema is visible swelling in certain parts of the body, especially the feet and legs. This swelling occurs as a result of excess fluid accumulating under the skin in the spaces around blood vessels. Edema is a symptom of serious disease until proven otherwise, requiring complete medical evaluation and physician monitoring.

    What causes it?
    Edema can occur as a result of certain situations (e.g., being pregnant, prolonged standing, or long airplane rides), obesity, age, or injury. Certain conditions, such as failure of the heart, kidney, or liver, a blood clot in the leg, insulin resistance syndrome (IRS), varicose veins, burns, bites, malnutrition, or surgery, can cause swelling in one or both legs.

    What role might cytokines play?
    Fat tissue produces a cytokine protein (angiotensinogen) that causes salt retention. Synthesis or release of this protein can be induced by a single meal if high in calories, fat, and/or carbohydrates. Fluid retention is maintained chronically by continuing to eat a high-fat, high-sugar, high-calorie diet. Inflammatory cytokines damage small blood vessels and cause them to leak with resultant fluid retention. Cytokines also affect hormones secreted from the adrenal gland, heart, and brain that further promote fluid retention.

    What results could I expect with MNT?
    Edema from any cause typically responds to the MNT Plan, usually by Food Phases 1 or 2. Patients on diuretics (fluid pills) or vasodilators (heart or high blood pressure medication) should be very alert to hypotension (low blood pressure) in Food Phase 1 or 2. Rapid fluid loss may occur, requiring discontinuance of medication. After your edema subsides in Food Phase 1 or 2, stay alert for signs of relapse. Depending on cause, relapse may occur after a single meal of a higher fat, higher carbohydrate food or for other reasons (e.g., large salt intake, menstrual swelling, or certain arthritis medicine). Swelling should quickly resolve with resumption of the plan.

    How can I measure symptom change on the plan?
    Talk with your doctor about what may be causing your swelling – cardiac illness, hypothyroidism, hypertension, OR perhaps a medication. If the latter, MNT will not reduce your symptoms; however, it can help determine if your edema is related to medication, depending on how quickly you see results without reducing medication dose or discontinuing altogether. Take a baseline measurement before beginning the Plan and again after each Food Phase or every four weeks.

  • What is it?
    Joint pain in the hip, knee, or feet all typically occur in those who are obese. The joints associated with these areas bear the weight of our frame and help to keep us upright. Stress on these joints, as our bodies adapt to changes in weight and body shape, can often lead to debilitating discomfort.

    The most common joint complaint is knee pain. The knee bears the brunt of increased weight and abnormal angle-stress from obesity. The knee is also subject to sudden twists and bends of unexpected slips and falls. This is often a problem for those who are obese and perhaps not as agile or flexible due to the excess weight. Minor tears in the ligaments, tendons, and cartilage (that result from these slips and falls) promote inflammation and swelling.

    Foot pain is a frequent complaint of obese patients. Foot pain can arise from the ankle joint, the nerves to the foot, and ligaments (plantar fasciitis or heel spur). All three conditions are more common in obesity for the same reasons noted with knee pain. The human foot was designed to bear weight down the shank of the leg and heel, rather than towards the toes (as it must do in obesity because of having a larger abdomen).

    Hip pain is the least frequent and most severe type of joint damage related to obesity. Pain from the hip joint is typically felt on the front of the hip. Hip pain requires expert diagnosis and rehab; you will need to see a joint specialist and possibly a physical therapist as well.

    What causes it?
    Joint pain and obesity are bedfellows. Joint pain may occur from increased strain and tearing of joint support (ligament, tendon, cartilage, bone) due to excessive weight and from abnormal joint angles from distorted weight distribution.

    On another level, joint pain is related to your body’s ability to repair damaged collagen – the support protein for the ligaments, tendons, cartilage, and bone. Obesity is associated with changes in your body’s hormone levels – the ones that impact your ability to repair collagen. Those who are obese tend to have low testosterone levels and low growth hormone levels, both of which are essential to collagen repair. Obesity is also associated with elevated level of cortisone, which destroys collagen. As we age, our ability to repair damaged collagen also decreases, making obesity and aging a very troubling combination.

    What role might cytokines play?
    Fat cells produce cytokines that promote immune inflammation that damages joint structures. The combination of increased weight, abnormal angles of movement, and increased immune damage with diminished collagen repair destroys joints and causes pain with disability. Those who are obese have more problems with joint injury because their bodies produce too much of a protein enzyme (metalloproteases) that destroys collagen. Since overproduction of this enzyme is linked to out-of-balance cytokines, PrescriptFit can offer significant benefits.

    What results could I expect with MNT?
    Knee pain often improves with the MNT Plan via decreased weight and diminished inflammation. In our clinic, decreased pain and medication requirements are seen long before major weight changes. Expert rehabilitation is vital. Abnormal weakness is just as important as obesity in promoting abnormal knee-angle stress. Ab strengthening should be a practiced daily in those with back, hip, knee, or foot pain.

    For improving foot pain, the Plan fosters weight loss and positive changes to posture that occur with reducing abdomen size. In addition, exercise and physical therapy as well as heel pads and arch supports will likely speed recovery. In our clinic, those using the MNT Plan often note improvement in foot pain, although usually at a slower rate than those experiencing improvement in knee pain.

    How can I measure symptom change on the plan?
    First, you need to be clear about what might be causing your joint pain. Talk to your doctor about what type of pain you have, when you first noticed it, the severity, and what treatment combination might be best for you. Next, you want to have a measurement of how severe the joint pain is for you. This will give you a baseline to compare with future measurements.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they might change using the Plan.

  • What is it?
    Back pain is an ongoing aching, soreness, and/or strained feeling in the back anywhere from the shoulders to the hips. It occurs in everyone at some point in life. It can result from some acute injury as well as chronic strain from poor posture, excessive weight, or both. Some health conditions, such as kidney infection, can cause severe pain and soreness in the mid portion of the back. You should always consult with your doctor about any unexplained back pain to be sure that you are not suffering from some illness that requires immediate treatment.

    What causes it?
    For chronic back pain that results from ongoing strain due to weight, cause is related to your body’s attempts to adjust your form to your changing body shape. As weight increases, abdominal size expands forward, causing stress along the ligaments and muscles connecting the vertebrae and collagen discs; the result – chronic pain.

    What role might cytokines play?
    There is evidence that cytokines produced by fat cells may lead to direct injury of collagen, weakening the ligaments, tendons, and spinal discs. Fat cells also produce inflaming cytokine proteins that may damage the lining of joints, including the small joints separating each vertebrae that allow you to easily bend, twist, and stretch the spine.

    What results could I expect with MNT?
    The MNT Plan will reduce the excessive weight and cytokines that contribute to back strain. Based on over a decade of clinical experience, 67 percent of patients who visit our clinic can discontinue medication for back pain within six months after they begin using the MNT Plan combined with physical therapy or rehabilitative exercise. For those taking anti-inflammatory medications for back pain, there’s an added bonus of stomach complaints improving – both from the reduced need to take the anti-inflammatory medications AND from eliminating irritating foods using the MNT Food Phase approach to identify those causing digestive problems.

    How can I measure symptom change on the plan?
    First, you need to be clear about what is causing your back pain. If you’re overweight, work in a job that requires lifting and other strenuous activities, or have recently strained your back, you should talk to your doctor about the benefits of the MNT Plan as well as physical therapy / rehabilitative exercise. If your back pain has occurred recently without explanation or apparent cause, your doctor will need to determine if there might be a more serious illness causing your discomfort that requires treatment.
    Next, you want to have a measurement of how severe your back pain is on a daily basis. This will give you a “baseline” to compare with future measurements.

    Most importantly, you (and your doctor) need a way to measure progress over time. Talk with your doctor at each regular visit about your symptoms and how they have changed using the Plan.
    As with any medical condition, treatment traditionally means taking medications to reduce symptoms. A number of prescription and over-the-counter medications can be taken to reduce the pain and inflammation in your back. With MNT, you may find that you will need to take less medication OR perhaps discontinue your medications entirely. If you are taking prescription medicines, talk to your doctor about when and how to cut down on what you take BEFORE you make any changes.

  • What is it?
    Depression is a chronic psychiatric condition that can be very debilitating or even life threatening. People who are depressed will typically feel sad and hopeless, may have changes in eating and sleeping patterns, and may move and think more slowly than usual. If severe, they may think about or plan suicide. The most common symptoms include being fatigued and unable to get motivated to participate in or enjoy activities that used to be pleasurable (including sex).

    What causes it?
    We don’t know exactly what causes depression; however, experts agree that some people are more prone to depression than others and that certain events or situations can put these people at risk for suffering from the illness. What we do know is that there are chemicals in the brains that impact how we handle stress, and these chemicals appear to be out of balance for those diagnosed with depression.

    Many medical conditions and some medications can contribute to symptoms of depression. People with depression often struggle with anxiety or mood swings as well. In addition, poor nutrition may contribute to depression. People who are depressed often either eat too much because it’s soothing or eat too little because they have no appetite or energy for eating. Nutritional balance certainly suffers either way.

    What role might cytokines play?
    Brain chemicals (called neurotransmitters) are intimately influenced by cytokines produced by fat, liver, and immune tissues. Depression is more common, for instance, in patients who overproduce C-Reactive Protein (or CRP) – common in those with metabolic syndrome, heart disease, and diabetes. Other cytokines called “interleukins” (IL-6, IL-2, and others) are closely tied to depression. The most dramatic example is the adverse side effect experienced by some when taking interferon (related to interleukin). Interferon is used for treating viral hepatitis; the profound depression that results in many cases often requires discontinuing the treatment.
    Other cytokine hormones (leptin, ghrelin, cholecystokinin) have dramatic effects on eating behavior, which in turn, may lead to metabolic problems that contribute to depression.

    The brain’s nerve cells have receptors that are very sensitive to changes in cytokine production, nutrition balance, and external factors. The common receptors known to affect depression (serotonin, dopamine, and norepinephrine) are also intricately tied to energy metabolism. Most antidepressants cause weight gain by impacting how these neurochemicals affect eating behavior and energy expenditure (exercise and activity). Many of these antidepressants also raise cytokine levels, occasionally dramatically, and can even cause or precipitate diabetes.

    What results could I expect with MNT?
    The symptoms of depression most likely to improve with MNT are fatigue (lack of energy), joy, motivation, and sex drive. Based on over a decade of clinical experience, these symptoms most dramatically improve during Food Phase 1 of the Plan.

    Because some antidepressant medications may contribute to weight gain and sexual dysfunction, it’s important to talk to your doctor about how possible medication side effects might impact your general health. MNT may play a vital role in managing side effects that could occur with those medications that may best treat your depressive symptoms.

    At the very least, the Amino Solution offers balanced nutrition for balanced brain function while reducing the levels of toxic cytokines known to be associated with depression. A lower, leaner weight will improve self confidence, make movement (exercise) easier, and will gain more favorable social interaction from others – factors all known to effect depression.

    How can I measure symptom change on the plan?
    First, visit your physician to determine what might be causing your depression. Next, rate your level of depression in the Workbook Calendar. This will give you a baseline measurement of how depressed you feel.

    Most importantly, you (and your doctor) need a way to measure progress over time.

    As you progress through the Plan, note how you feel when adding each food category. If a particular food seems to be related to when you experience symptoms of depression, share this information with your doctor and use the knowledge you gain to modify your diet.

    As with any medical condition, treatment may involve taking medications to reduce your depression symptoms. Many of these medications require close physician supervision to change the dose or stop taking them. With PrescriptFit, you may find that as your symptoms lessen, you will need to take less medication OR perhaps discontinue your medications entirely.

PrescriptFit is clinically proven to help patients decrease medications for a number of illnesses. For this reason, we recommend physician supervision while on this program.